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^ Bunney BS, Chiodo LA, Freeman AS. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous
system. Annals of the New York Academy of Sciences. 1985;448:345-51.
^ González-Puga C, García-Navarro A, Escames G, León J, López-Cantarero M, Ros E, Acuña-Castroviejo D. Selective CCK-A but not CCK-B receptor
antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. Journal of Pineal Research. 2005 Oct;39(3):243-50.
doi:10.1111/j.1600-079X.2005.00239.x PMID 16150104
^ Bergemann W, Consentius K, Braun HE, Hirschmann H, Marowski B, Munck A, Rehs HU, Stopik D, Wilke G. Duodenal ulcer - multicenter double-blind study
with proglumide. (German) Medizinische Klinik. 1981 Apr 10;76(8):226-9.
^ Tariq M, Parmar NS, Ageel AM. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. Journal of Pharmacology and Experimental
Therapeutics. 1987 May;241(2):602-7.
^ McCleane GJ. The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine. Clinical Journal of Pain. 2003
^ Watkins LR, Kinscheck IB, Mayer DJ. Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. Science. 1984 Apr
^ Tang J, Chou J, Iadarola M, Yang HY, Costa E. Proglumide prevents and curtails acute tolerance to morphine in rats. Neuropharmacology. 1984
^ Bernstein ZP, Yucht S, Battista E, Lema M, Spaulding MB. Proglumide as a morphine adjunct in cancer pain management. Journal of Pain and Symptom
Management. 1998 May;15(5):314-20.
^ McCleane GJ. The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. Anesthesia and
Analgesia. 1998 Nov;87(5):1117-20.
^ Rezvani A, Stokes KB, Rhoads DL, Way EL. Proglumide exhibits delta opioid agonist properties. Alcohol and Drug Research. 1987;7(3):135-46.
We are proud to offer you PROGLUMIDE. 100% pure product with no fillers or additives, crafted  
in The USA for The discriminating vitamin and supplement connoisseur.

                                     AND NOW MORE ABOUT PROGLUMIDE                                    
We have taken a break from Kratom to focus on bringing you Some new and effective supplements
that can potentates your pain medication by making it possible to get a much stronger effect from
them without adding more pain killer through using our safe products. The first is, Pure Proglumide
also known as Milid, Milide, Xilamide; Xylamide; Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-
oxo-, (+-)-

Proglumide inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin
antagonist,[1] which blocks both The CCKA and CCKB subtypes.[2] It was used mainly in The
treatment of stomach ulcers,[3][4] although it has now been largely replaced by newer drugs for this

An interesting side effect of proglumide is that it enhances The analgesia produced by opioid drugs,[5]
and can prevent or even reverse The development of tolerance to opioid drugs.[6][7] This can make it a
useful adjuvant treatment to use alongside opioid drugs in The treatment of chronic pain conditions
such as cancer, where opioid analgesics may be required for long periods and development of
tolerance reduces clinical efficacy of these drugs.[8][9]

Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic
effects.[10] This is NOT The lesser quality, "Proglumetacin" also called Afloxan, Protaxon and Proxil)
Which is a non-steroidal anti-inflammatory which is a class of substances that can cause horrendous
side effects which can be extremely dangerous and include internal bleeding! Our Proglumide is
unadulterated and created here in The USA through a professional and consistent source, for an
interesting and often sought after product. We believe you will find it a both satisfying and worth
experiencing. You will find impeccable quality as well as a helpful and informative staff here at Kratom
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